Publications by authors named "Julia Jakobi"
Background: Computed tomography (CT) is a main contributor to artificial low-dose exposure. Understanding the biological effects induced by CT exposure and their dependency on the characteristics of photon spectra is essential for knowledge-driven risk assessment. In a previous gene expression study, we have identified upregulation of , , , and after ex vivo exposure with single-energy CT and dual-energy CT (DECT).
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- - Dual-energy CT offers similar or lower radiation doses than single-energy CT while enhancing diagnostic capabilities, but it may still cause cellular damage due to its unique photon properties.
- - A study analyzed blood samples from three healthy individuals, comparing the biological effects of dual-energy and single-energy CT scans, focusing on early gene regulation and DNA double strand breaks (DSBs).
- - Results showed no significant difference in biological effectiveness between dual-energy and single-energy CT, but both induced higher rates of DSBs and upregulated specific radiation-induced genes, indicating that CT scans pose a risk to gene integrity despite lower doses.
Sulfur mustard (SM) is a chemical warfare agent that can damage DNA via alkylation and oxidative stress. Because of its genotoxicity, SM is cancerogenic and the progenitor of many chemotherapeutics. Previously, we developed an SM-resistant cell line via chronic exposure of the popular keratinocyte cell line HaCaT to increasing doses of SM over a period of 40 months.
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