Design and Assessment of First-Generation Heterobifunctional PPARα/STING Modulators.

Inflammatory retinal diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD) are prominent causes of blindness in industrialized countries. The complexity of these diseases, involving diverse cell types and pathways that give rise to a multifactorial pathogenesis, complicates drug discovery. As such, therapies exhibiting polypharmacology are expected to improve outcomes through broader disease stage coverage and beneficial spatiotemporal effects.

Correction to "The interpersonal costs of dishonesty: How dishonest behavior reduces individuals' ability to read others' emotions" by Lee et al. (2019).

Reports an error in "The interpersonal costs of dishonesty: How dishonest behavior reduces individuals' ability to read others' emotions" by Julia J. Lee, Ashley E. Hardin, Bidhan Parmar, and Francesca Gino (, 2019[Sep], Vol 148[9], 1557-1574).

Design, Synthesis, and Structure-Activity Relationships of Biaryl Anilines as Subtype-Selective PPAR-alpha Agonists.

The role of peroxisome proliferator-activated receptor alpha (PPARα) in retinal biology is clarifying, and evidence demonstrates that novel PPARα agonists hold promising therapeutic utility for diseases like diabetic retinopathy and age-related macular degeneration. Herein, we disclose the design and initial structure-activity relationships for a new biaryl aniline PPARα agonistic chemotype. Notably, this series exhibits subtype selectivity for PPARα over other isoforms, a phenomenon postulated to be due to the unique benzoic acid headgroup.

The interpersonal costs of dishonesty: How dishonest behavior reduces individuals' ability to read others' emotions.

In this research, we examine the unintended consequences of dishonest behavior for one's interpersonal abilities and subsequent ethical behavior. Specifically, we unpack how dishonest conduct can reduce one's generalized empathic accuracy-the ability to accurately read other people's emotional states. In the process, we distinguish these 2 constructs from one another and demonstrate a causal relationship.

Different physiological reactions when observing lies versus truths: Initial evidence and an intervention to enhance accuracy.

Humans consistently face the challenge of discerning liars from truth-tellers. Hundreds of studies in which observers judge the veracity of laboratory-created lies and truths suggest that this is a difficult task; in this context, lie-detection accuracy is notoriously poor. Challenging these findings and traditional methodologies in lie-detection research, we draw upon the somatic marker hypothesis and research on interoception to find that: (a) people experience physiological reactions indicating increased sympathetic arousal while observing real, high-stakes lies (vs.

Lay theories of effortful honesty: Does the honesty-effort association justify making a dishonest decision?

Are our moral decisions and actions influenced by our beliefs about how much effort it takes to do the right thing? We hypothesized that the belief that honesty is effortful predicts subsequent dishonest behavior because it facilitates one's ability to justify such actions. In Study 1 ( = 210), we developed an implicit measure of people's beliefs about whether honesty is effortful, and we found that this lay theory predicts dishonesty. In Study 2 ( = 339), we experimentally manipulated individuals' lay theories about honesty and effort and found that an individual's lay theory that honesty is effortful increased subsequent dishonesty.

Polluted Morality: Air Pollution Predicts Criminal Activity and Unethical Behavior.

Air pollution is a serious problem that affects billions of people globally. Although the environmental and health costs of air pollution are well known, the present research investigates its ethical costs. We propose that air pollution can increase criminal and unethical behavior by increasing anxiety.