Publications by authors named "Julia Hyun"
Patients with xeroderma pigmentosum (XP) frequently develop skin cancers early in life, including cutaneous squamous cell carcinoma (cSCC). The median age of death is 32 years and 60% of XP patients die before the age of 20 years. cSCC in patients with XP exhibits an exceptionally high mutation burden, suggesting a favorable response to immune checkpoint inhibitors (ICIs).
View Article and Find Full Text PDF[Cutaneous leishmaniasis misdiagnosed as epithelial skin cancer].
Dermatologie (Heidelb)
February 2025
Cutaneous leishmaniasis, transmitted by sand flies of the genus Phlebotomus, is one of the most important traveler's dermatoses in Germany. In recent years, an increased incidence of the disease has been observed in travelers returning from endemic areas, including the Mediterranean region of Spain and Italy. In these regions, Leishmania infantum belonging to the Leishmania donovani complex is characteristically the most frequently detected pathogen.
View Article and Find Full Text PDF[Bullous mycosis fungoides-clinical indicator for an aggressive course of disease].
Dermatologie (Heidelb)
November 2024
Mycosis fungoides (MF) is defined as the most common cutaneous T‑cell lymphoma (CTCL). The bullous form is considered one of its numerous variants. Only a few cases of this rare entity have been described.
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- Tinea capitis, a contagious fungal infection mainly caused by dermatophytes like T. tonsurans, has been linked to transmission in barber shops in Germany through unsterilized shaving tools.
- A study involving 18 young male patients who developed symptoms after haircuts revealed the presence of T. tonsurans in all samples, indicating transmission via hairdressing equipment.
- Effective treatments included antifungal medications such as terbinafine and itraconazole, underscoring the importance of proper sterilization practices in preventing infections.
Background And Objectives: Once classic treatments such as chemotherapy or radiation therapy have been exhausted, only few therapeutic options remain for extensive skin tumors or cutaneous metastases. In such cases, electrochemotherapy may be considered as alternative therapy.
Patients And Methods: In this retrospective study, clinical features, treatment response, and adverse effects were evaluated in 56 patients treated with electrochemotherapy at six German dermatology departments.
Localized scleroderma (LS) is a connective skin disease with marked sclerosis of the skin as the most prominent feature. Transforming growth factor beta (TGF-beta) plays a central role in the pathogenesis of sclerotic skin diseases. Recently, special attention was contributed to a family of transcription factor proteins involved in TGF-beta signal transduction from cell surface to the nucleus, the so-called SMADs.
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- Intertriginous psoriasis (IP) management has been challenging due to side effects of long-term corticosteroids, leading to a study comparing pimecrolimus, calcipotriol, and betamethasone as alternative treatments.
- A 4-week double-blind study at Ruhr University involved 80 adults to analyze the effectiveness of these treatments, focusing on the Modified Psoriasis Area and Severity Index (M-PASI) score.
- Results showed that 0.1% betamethasone was the most effective treatment, significantly reducing M-PASI scores and itching, outperforming the other options.
Background: In previous trials, UV therapy has been demonstrated to be effective in the treatment of localized scleroderma (LS). To date, a randomized comparison study to evaluate the efficacy and safety of different, commonly used phototherapeutic modalities in LS is still outstanding.
Objective: The aim of this study was to compare the safety and efficacy of low-dose (LD) UVA1, medium-dose (MD) UVA1, and narrowband (NB) UVB phototherapy in the treatment of LS.