Predictors of sexual aggression among gay men and lesbian women: An application of Malamuth's confluence model.

The present study investigated whether the core constructs of Malamuth's confluence model (i.e., hostility against individuals of the same sex and sexual orientation [HASSO], impersonal sexuality [IS], and high dominance/low nurturance [HDLN]) could predict sexual aggressive behavior (SA) of gay men against other gay men and of lesbian women against other lesbian women.

Re-expression of IGF-II is important for beta cell regeneration in adult mice.

Background: The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the adult is not known. In this study we investigated the effect of IGF-II on beta cell regeneration.

Automated detection and quantification of fluorescently labeled synapses in murine brain tissue sections for high throughput applications.

The automated detection and quantification of fluorescently labeled synapses in the brain is a fundamental challenge in neurobiology. Here we have applied a framework, based on machine learning, to detect and quantify synapses in murine hippocampus tissue sections, fluorescently labeled for synaptophysin using a direct and indirect labeling method with FITC as fluorescent dye. In a pixel-wise application of the classifier, small neighborhoods around the image pixels are mapped to confidence values.

Integrating semantic annotation and information visualization for the analysis of multichannel fluorescence micrographs from pancreatic tissue.

The challenging problem of computational bioimage analysis receives growing attention from life sciences. Fluorescence microscopy is capable of simultaneously visualizing multiple molecules by staining with different fluorescent dyes. In the analysis of the result multichannel images, segmentation of ROIs resembles only a first step which must be followed by a second step towards the analysis of the ROI's signals in the different channels.

Efficient computation of absent words in genomic sequences.

Background: Analysis of sequence composition is a routine task in genome research. Organisms are characterized by their base composition, dinucleotide relative abundance, codon usage, and so on. Unique subsequences are markers of special interest in genome comparison, expression profiling, and genetic engineering.

BACCardI--a tool for the validation of genomic assemblies, assisting genome finishing and intergenome comparison.

Summary: We provide the graphical tool BACCardI for the construction of virtual clone maps from standard assembler output files or BLAST based sequence comparisons. This new tool has been applied to numerous genome projects to solve various problems including (a) validation of whole genome shotgun assemblies, (b) support for contig ordering in the finishing phase of a genome project, and (c) intergenome comparison between related strains when only one of the strains has been sequenced and a large insert library is available for the other. The BACCardI software can seamlessly interact with various sequence assembly packages.