Publications by authors named "Julia Hegert"
Fetal intracranial teratoma presents a rare and devastating diagnosis. Typically, this condition is first detected during routine prenatal ultrasounds, appearing as an irregular heterogeneous lesion. Further insights are gained through fetal magnetic resonance imaging (MRI), better characterizing the anomaly.
View Article and Find Full Text PDFImportance: Loss of smell is an early and common presentation of COVID-19 infection. Although it has been speculated that viral infection of olfactory neurons may be the culprit, it is unclear whether viral infection causes injuries in the olfactory bulb region.
Objective: To characterize the olfactory pathology associated with COVID-19 infection in a postmortem study.
Article Synopsis
- Heterozygous mutations in X-linked genes such as MeCP2 lead to different outcomes in girls and boys, with girls experiencing developmental delays and boys facing severe conditions like epileptic encephalopathy due to the loss of a single allele.* -
- Research involving a deceased 2-month-old boy with a specific mutation, along with mouse models, indicates that cerebellar hypoplasia is linked to early neurodegeneration rather than issues with neuron development or migration.* -
- The study concludes that X-linked neurodevelopmental disorders like MeCP2 mutations reflect neurodegenerative processes, with female mutations being less severe due to random X-chromosome inactivation allowing some cells to still express functional genes.*
A 72-year-old male smoker was brought into the emergency department complaining of 4 months of progressive dyspnea and fatigue. Computed tomography angiogram of the lungs was negative for pulmonary embolism; however, a 10 cm right upper lobe mass and multiple bilateral pulmonary nodules were identified. While computed tomography scan of the head showed no lesions in the brain, there was osseous destruction of the right mandible.
View Article and Find Full Text PDFDiffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children, with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and to the selection of therapies on the basis of assumptions that DIPGs are molecularly similar to adult disease. Recent studies have unraveled the unique genetic makeup of this brain cancer, with nearly 80% found to harbor a p.
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