Publications by authors named "Julia H Indik"
Pulsed Field Ablation: The Temptation for More While Keeping It Safe.
Circ Arrhythm Electrophysiol
October 2024
Article Synopsis
- The "2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Patients With Atrial Fibrillation" aims to provide updated recommendations for clinicians treating atrial fibrillation patients.
- A thorough literature review was conducted to gather evidence from various medical databases, including studies and reviews published on human subjects from May to November 2022.
- The guideline updates previous recommendations, introducing new strategies for thromboembolic risk assessment, anticoagulation, and methods for prevention and management of atrial fibrillation.
Article Synopsis
- The 2023 guideline aims to provide healthcare professionals with updated recommendations for diagnosing and managing patients with atrial fibrillation.
- A thorough literature review was conducted to gather relevant studies and evidence from multiple databases, ensuring the guideline reflects current knowledge and practices.
- The guidelines build upon earlier recommendations, introducing new insights on thromboembolic risk, anticoagulation, surgical options, and preventive measures related to atrial fibrillation.
Article Synopsis
- Cardiac physiologic pacing (CPP) includes techniques like cardiac resynchronization therapy (CRT) and conduction system pacing (CSP) aimed at reducing heart failure in patients with issues in heart rhythm.
- The clinical guideline outlines recommendations for when to use CRT in heart failure patients, how to select suitable candidates, and key steps for pre-procedure preparation and ongoing care.
- It also highlights areas where more research is needed to improve understanding and application of these pacing therapies, especially for children.
Cardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT) and conduction system pacing (CSP), has emerged as a pacing therapy strategy that may mitigate or prevent the development of heart failure (HF) in patients with ventricular dyssynchrony or pacing-induced cardiomyopathy. This clinical practice guideline is intended to provide guidance on indications for CRT for HF therapy and CPP in patients with pacemaker indications or HF, patient selection, pre-procedure evaluation and preparation, implant procedure management, follow-up evaluation and optimization of CPP response, and use in pediatric populations. Gaps in knowledge, pointing to new directions for future research, are also identified.
View Article and Find Full Text PDFRhythm Control Treatment for Atrial Fibrillation Is Not Just for the Healthy.
Circ Arrhythm Electrophysiol
May 2023
Article Synopsis
- The study aimed to understand the real-world adoption and outcomes of conduction system pacing (CSP), specifically His bundle pacing (HBP) and left bundle branch area pacing (LBBAP), through an online survey conducted from November 2020 to February 2021.
- Out of 140 institutions across five continents, 127 reported experience with CSP lead implantation, revealing low but increasing adoption rates of CSP compared to traditional pacing methods in 2019.
- The study concluded that while CSP lead implantation is growing in popularity, it is not yet the standard practice at many institutions, indicating a need for further education and promotion of this technique.
Article Synopsis
- Simulation technology can effectively enhance coronary angiographic (CA) image interpretation skills among medical trainees beyond traditional teaching methods, as shown in a randomized study.
- The study involved 105 participants, including medical students, residents, and fellows, who were divided into two groups: one receiving simulation training alongside didactic teaching and the other receiving didactic teaching alone.
- Results indicated that those in the simulation group had significantly higher improvement in test scores, particularly residents, emphasizing the need for integrating simulation training into cardiovascular fellowship programs.
Background: Patients with atrial fibrillation are increasingly prescribed a direct oral anticoagulant (DOAC) over warfarin and seek to avoid anticoagulation even without a history of major bleeding. This study explores the outcomes of patients implanted with a Watchman device in relation to anticoagulation choice (warfarin versus DOAC) in the post-procedure period and a history of bleeding.
Methods: Patients implanted with a Watchman device at a single center were retrospectively analyzed.
Previous reports indicate that IL18 is a novel candidate gene for diastolic dysfunction in sickle cell disease (SCD)-related cardiomyopathy. We hypothesize that interleukin-18 (IL-18) mediates the development of cardiomyopathy and ventricular tachycardia (VT) in SCD. Compared with control mice, a humanized mouse model of SCD exhibited increased cardiac fibrosis, prolonged duration of action potential, higher VT inducibility in vivo, higher cardiac NF-κB phosphorylation, and higher circulating IL-18 levels, as well as reduced voltage-gated potassium channel expression, which translates to reduced transient outward potassium current (Ito) in isolated cardiomyocytes.
View Article and Find Full Text PDFCoronavirus disease (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The symptoms of the disease range from asymptomatic to mild respiratory symptoms and even potentially life-threatening cardiovascular and pulmonary complications. Cardiac complications include acute myocardial injury, arrhythmias, cardiogenic shock and even sudden death.
View Article and Find Full Text PDFBackground: The purpose of this study was to identify predictors of mortality and potentially modifiable factors related to arrhythmias in patients that undergo transcatheter aortic valve replacement (TAVR). Patients that undergo TAVR are at risk for complete heart block requiring pacemaker implant. Additionally, other arrhythmias, specifically atrial fibrillation (AF), are common in this population.
View Article and Find Full Text PDFArrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This designation includes, but is not limited to, arrhythmogenic right/left ventricular cardiomyopathy, cardiac amyloidosis, sarcoidosis, Chagas disease, and left ventricular noncompaction.
View Article and Find Full Text PDFArrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This designation includes, but is not limited to, arrhythmogenic right/left ventricular cardiomyopathy, cardiac amyloidosis, sarcoidosis, Chagas disease, and left ventricular noncompaction.
View Article and Find Full Text PDFBackground: Observational studies have explored the safety of magnetic resonance (MR) scanning of patients with cardiac implantable electronic devices (CIEDs) that are not Food and Drug Administration approved for MR scanning ("nonconditional"). However, concern has been raised that MR scanning that includes the thoracic region may pose a higher risk. This study examines the safety of MR scanning of thoracic versus nonthoracic regions of patients with CIEDs.
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