Publications by authors named "Julia Guther"
Article Synopsis
- ESBL-producing Enterobacterales (ESBL-PE) are common in long-term care facilities (LTCFs), prompting a study across six sites in Europe to assess how residents acquire these bacteria and the associated risk factors.
- Over 32 weeks, researchers screened 299 residents and found that 16.4% were colonized at the start, with a new acquisition rate of 0.79 per 1000 resident-days, influenced by factors like age, vascular disease, and antibiotic use.
- Key findings highlight the importance of infection control measures, such as ensuring hand sanitizers and adequate nurse staffing, as well as using genomic surveillance to inform strategies for managing ESBL-PE in LTCFs.
Background: Carbapenem-resistant strains are on the rise worldwide. This study characterized clinical isolates of from three Nigerian hospitals for carbapenem resistance.
Methods: Strains isolated from wounds ( = 88), urine/catheter tips ( = 25), sputum/tracheotomy aspirates ( = 5), ear swabs ( = 4) and vaginal swabs ( = 1) were identified by MALDI-TOF and antibiotic susceptibility testing was performed using the VITEK 2 system.
Objectives: To determine prevalence, incidence, and factors associated with Pseudomonas aeruginosa (PA) intestinal carriage in residents of long-term care facilities (LTCFs) and to understand the population structure of this pathogen in LTCFs from two European countries.
Methods: We assessed the prevalence of PA intestinal carriage and the incidence of acquisition by collecting fecal samples from 403 residents of 20 LTCFs. We collected 289 environmental samples from sinks and drinking water.
Objectives: To assess the extent to which food items are a source of extended-spectrum β-lactamase (ESBL) -producing Escherichia coli (ESBL-Ec) and ESBL-producing Klebsiella pneumoniae (ESBL-Kp) for humans in five European cities.
Methods: We sampled 122 human polluted (hp)-environments (sewers and polluted rivers, as a proxy of human contamination) and 714 food items in Besançon (France), Geneva (Switzerland), Sevilla (Spain), Tübingen (Germany) and Utrecht (The Netherlands). A total of 254 ESBL-Ec and 39 ESBL-Kp isolates were cultured.
Objectives: This study aimed to determine rates and risk factors of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) acquisition and transmission within households after hospital discharge of an ESBL-PE-positive index patient.
Methods: Two-year prospective cohort study in five European cities. Patients colonized with ESBL-producing Escherichia coli (ESBL-Ec) or Klebsiella pneumoniae (ESBL-Kp), and their household contacts were followed up for 4 months after hospital discharge of the index case.
Objectives Serological assays for detection of SARS-CoV-2 antibodies are increasingly used during the COVID-19 pandemic caused by the SARS-Coronavirus-2. Here we evaluated the analytical and clinical performance of three commercially available SARS-CoV-2 antibody assays. Methods A total of 186 samples from 58 patients with PCR-confirmed COVID-19 infection were measured using SARS-CoV-2 antibody assays by Siemens Healthineers, Roche Diagnostics and Euroimmun.
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