Publications by authors named "Julia Guido"
Background And Objectives: Craniosynostosis can lead to progressive cranial and skull base deformities and can be associated with increased intracranial pressure (ICP), ophthalmological manifestations, behavioral changes, and developmental delay. Most published data on the incidence of elevated ICP include older children undergoing open surgical correction. Endoscopic-assisted release of fused sutures with postoperative helmet therapy is an established method for managing craniosynostosis presenting at an early age; however, the immediate effect of this approach on ICP in a young cohort has not been previously reported.
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- This study examines how patient-reported outcomes (PROs) like the CFQ-R Respiratory score and CRISS can track changes over time and identify acute respiratory events in children with cystic fibrosis (CF).
- Conducted over two years, the research involved regular assessments of children aged 6-18 and highlighted that while symptom scores remained stable during clinically stable visits, certain score changes were effective in predicting acute events.
- Results indicated that the parent-proxy CFQ-R score was more accurate than the self-reported version for detecting acute issues, and the predictive values improved significantly when these scores were combined with lung function measurements (LCI and FEV).
Article Synopsis
- The lung clearance index (LCI) is a useful measure for detecting early lung disease in children with cystic fibrosis, especially during their preschool years.
- A study followed children with cystic fibrosis and healthy peers from preschool to early school age, observing LCI every 3 months for 2 years.
- Results showed that while LCI values in cystic fibrosis children remained stable during school age, preschool LCI levels were strong predictors of future lung health, highlighting the importance of early intervention.
Article Synopsis
- * A study followed 98 school-age children with CF for 2 years and found that during acute respiratory events, LCI worsened by +8.9%, while FEV% predicted decreased by -6.6%.
- * The LCI was more sensitive than FEV% in identifying worsening lung function during these events, and neither measure returned to baseline levels at the next follow-up, indicating incomplete recovery.