Risk factors and epidemiology of spontaneous intestinal perforation among infants born at 22-24 weeks' gestational age.

Objective: To describe the epidemiology, risk factors, and timing of spontaneous intestinal perforation (SIP) among infants born at 22-24 weeks' gestational age (GA).

Study Design: Observational cohort study among infants born at 22-24 weeks' GA in 446 neonatal intensive care units.

Results: We identified 9712 infants, of whom 379 (3.