Publications by authors named "Julia Flammer"
Article Synopsis
- Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) can be preceded by infections, and this study examines two MOGAD patients who also had latent syphilis infections.
- Clinical presentations included cervical myelitis and unilateral optic neuritis, with one patient also living with HIV and another with hepatitis B.
- The study found that patient antibodies reacted to both MOG and another unspecified antigen, suggesting a possible link between syphilis and autoimmune neuroinflammation, warranting further investigation into infectious triggers for MOGAD.
Importance: Differential diagnosis of patients with seronegative demyelinating central nervous system (CNS) disease is challenging. In this regard, evidence suggests that immunoglobulin (Ig) A plays a role in the pathogenesis of different autoimmune diseases. Yet little is known about the presence and clinical relevance of IgA antibodies against myelin oligodendrocyte glycoprotein (MOG) in CNS demyelination.
View Article and Find Full Text PDFSeizures and epilepsy can result from various aetiologies, yet the underlying cause of several epileptic syndromes remains unclear. In that regard, autoimmune-mediated pathophysiological mechanisms have been gaining attention in the past years and were included as one of the six aetiologies of seizures in the most recent classification of the International League Against Epilepsy. The increasing number of anti-neuronal antibodies identified in patients with encephalitic disorders has contributed to the establishment of an immune-mediated pathophysiology in many cases of unclear aetiology of epileptic syndromes.
View Article and Find Full Text PDFA patient-tailored, ex vivo drug response platform for glioblastoma (GBM) would facilitate therapy planning, provide insights into treatment-induced mechanisms in the immune tumor microenvironment (iTME), and enable the discovery of biomarkers of response. We cultured regionally annotated GBM explants in perfusion bioreactors to assess iTME responses to immunotherapy. Explants were treated with anti-CD47, anti-PD-1, or their combination, and analyzed by multiplexed microscopy [CO-Detection by indEXing (CODEX)], enabling the spatially resolved identification of >850,000 single cells, accompanied by explant secretome interrogation.
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