Publications by authors named "Julia Eisele"
Front Pharmacol
February 2022
Article Synopsis
- The binary C2 toxin consists of two proteins: C2I (the enzyme) and C2II (the binding/transport subunit), which work together to disrupt cell function by entering mammalian cells and modifying actin.
- Proteolytically activated C2IIa forms heptameric structures that bind to cell receptors, leading to pore formation in endosomal membranes for the translocation of C2I into the cell's cytosol, where it causes actin depolymerization and cell rounding.
- Interestingly, C2IIa alone caused morphological changes in neutrophils (PMNs) but not in other cell types, indicating a selective toxic effect; it also inhibited PMN
