Large differences in adiponectin levels have no clear effect on multiple sclerosis risk: A Mendelian randomization study.

Background: Mendelian randomization (MR) studies have demonstrated strong support for an association between genetically increased body mass index and risk of multiple sclerosis (MS). The adipokine adiponectin may be a potential mechanism linking body mass to risk of MS.

Objective: To evaluate whether genetically increased adiponectin levels influence risk of MS.