Publications by authors named "Julia Cristina Colombari"
Characterization of Renal OAT3 and Hepatic CYP3A Activities in Pregnant Women with Acute Pyelonephritis Using the Endogenous Biomarker Cortisol and 6β-Hydroxycortisol.
J Clin Pharmacol
January 2025
This study evaluates the impact of acute pyelonephritis in pregnant women on the in vivo activity of renal OAT3 using the endogenous biomarker (EB) 6β-hydroxycortisol (6β-OHF) renal clearance (CL 6β-OHF) and AUC validated by correlating with the secretion clearance (CL) of the probe drug furosemide. Additionally, 6β-OHF formation clearance (CL 6β-OHF) as well as urinary (Ae/Ae) and plasma (AUC/AUC) ratios were also evaluated as EB for hepatic CYP3A activity. Pregnant women in their third trimester of gestation, diagnosed with acute pyelonephritis, were recruited before (pre-treatment, n = 8) and after (post-treatment, n = 8) cefuroxime treatment and resolution of acute pyelonephritis.
View Article and Find Full Text PDFDetermination of furosemide and its glucuronide metabolite in plasma, plasma ultrafiltrate and urine by HPLC-MS/MS with application to secretion and metabolite formation clearances in non-pregnant and pregnant women.
J Pharm Biomed Anal
October 2023
Article Synopsis
- Furosemide (FUR) is used in studies to evaluate renal transporters OAT1 and OAT3 for drug-drug interactions, particularly involving probenecid as an inhibitor.
- The study aimed to create reliable methods for analyzing FUR and its metabolite FUR-GLU in different bodily fluids for pharmacokinetics in pregnant and non-pregnant women.
- Results showed significant differences in FUR clearance rates and unbound fractions between pregnant and non-pregnant women, indicating the impact of probenecid on FUR metabolism in pregnancy.