Inhaled salbutamol plus ipratropium in moderate and severe asthma crises in children.

Background: The combination of inhaled β(2) agonists and anticholinergics is recommended for children with acute asthma, although there are few randomized controlled trials. The aim of the study was to determine whether salbutamol plus ipratropium bromide improves oxygenation and lung function and reduces the frequency of hospitalization in children with asthma crises.

Methods: A prospective, randomized, double-blind study of children aged 2-18 years with moderate to severe asthma crises.