Publications by authors named "Julia Christl"

Introduction: Correctional institutions are challenged by increasing numbers of older prisoners. Existing literature highlights the vulnerability of this group that is reflected by various somatic and mental health issues including cognitive dysfunctions. Although cognitive training studies in various target groups of older people have been conducted, there is lack of data regarding cognitive training in older prisoners.

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  • Lithium is the preferred treatment for bipolar disorder and severe unipolar depression in both older and younger patients.
  • Despite being effective and generally safe, caution is needed when prescribing lithium to older individuals due to age-related health issues.
  • A review of current literature highlights the importance of monitoring and managing comorbidities to prevent complications like nephropathy and intoxication in elderly patients on lithium.
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With increasing numbers of older prisoners, effective strategies for preventing and treating age-associated diseases, such as cognitive disorders, are needed. As pharmacological therapies are limited, non-pharmacological interventions are increasingly recognized as potential treatment strategies. One approach is cognitive training (CT).

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Introduction: While lithium (Li) has been well established for the treatment of bipolar disorder, geriatric patients require special attention when it comes to issues of drug safety. Declining renal function, amongst other medical conditions, and polypharmacy may pose increased risks. Only a few previous studies have addressed the management of Li in geriatric patients.

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Background: Lithium is considered the gold standard for the treatment of bipolar affective disorder for the prevention of recurrence of manic and depressive episodes and for augmentation treatment in unipolar severe depressive episodes. The indications for treatment with lithium do not differ for older or younger patients. Nevertheless, there are a number of aspects to be considered with respect to drug safety in the group of old patients.

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Objective: Hypothermia is a potentially lethal adverse reaction to typical and atypical antipsychotic drugs (APD). Among predisposing factors are advanced age and comorbid somatic diseases. The aim of this study was to assess the incidence of hypothermia and quantify risk factors.

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Background: Increased expression of the astroglial Ca2+-binding protein S100B has been observed in various neurodegenerative diseases and also seems to play a role in the unfolding of pathophysiological events at early stages of Alzheimer's disease (AD).

Objective: To examine the association of cerebrospinal fluid (CSF) levels of S100B with 1) established CSF core biomarkers total tau (tau), hyperphosphorylated tau (p-tau), and amyloid β1-42 (Aβ1-42) as well as neuron-specific enolase (NSE) CSF levels and 2) cognition in early AD and mild cognitive impairment (MCI) due to AD (MCI-AD).

Methods: Retrospective study assessing 49 pooled charts of Memory Clinic and inpatients diagnosed with AD (N = 26) and MCI-AD (N = 23) according to the National Institute of Aging and Alzheimer's Disease Association (NIA-AA) criteria.

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  • Major depression disorder (MDD) is a leading cause of disability for individuals over 60, and its impact on cognitive function is linked to white matter (WM) disruption in the brain.
  • A study compared WM integrity, measured by fractional anisotropy (FA), in 17 elderly MDD patients and 18 similar-aged controls, revealing lower FA in the right posterior cingulate cluster among those with MDD.
  • Findings indicated that lower FA in the right PCC correlated with better performance on verbal naming tasks in MDD patients, suggesting cognitive deficits may stem from WM integrity loss, while controls showed no such correlations.
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