Publications by authors named "Julia C Conway"
Background: Surgical correction of orofacial clefts greatly mitigates negative outcomes. However, access to reconstructive surgery is limited in developing countries. The present study reviews epidemiological data from a single charitable organization, Smile Train, with a database of surgical cases from 33 African countries from 2001-2011.
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- Reengineering AAV receptor footprints can improve variants for clinical use.
- A panel of synthetic AAV2 vectors was developed by modifying a heparan sulfate receptor footprint, resulting in chimeric capsids with systemic delivery capabilities in mice.
- One variant, AAV2i8, demonstrated enhanced muscle targeting, reduced liver accumulation, and a unique antigenic profile, making it promising for gene therapy in musculoskeletal disorders.