Publications by authors named "Julia Borgolte"
Midkine is a pleiotropic factor, which is involved in angiogenesis. However, its mode of action in this process is still ill defined. The function of midkine in arteriogenesis, the growth of natural bypasses from pre-existing collateral arteries, compensating for the loss of an occluded artery has never been investigated.
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- Scientists studied a protein called midkine (MK) to see how it helps certain white blood cells, called PMNs, stick to blood vessels during inflammation.
- They found that mice without MK had trouble with their PMNs sticking and moving out of the blood vessels during inflammation, but giving them MK helped fix this problem.
- MK helps PMNs stick better by changing a part of the PMN that helps it grab onto other cells, but it doesn’t make PMNs more active in causing inflammation.
Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis.
Am J Physiol Heart Circ Physiol
August 2012
The cytokine midkine (MK) promotes tumor growth mainly by inducing angiogenesis. Here, we identified the source of MK in the vascular system under hypoxic conditions and demonstrated the relevance of MK during ischemia of normal tissue. Hypoxia increased MK protein expression in human polymorphonuclear neutrophils (PMN), monocytes, and human umbilical vein endothelial cells (HUVEC) compared with normoxia.
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