Publications by authors named "Julia Boehnke"
Article Synopsis
- COVID-19 severity is influenced by various factors such as age and obesity, but the exact mechanisms behind these risks remain unclear.
- A meta-analysis involving 1,471 participants examined the relationship between genetic and phenotypic factors and the expression of ACE2 in adipose tissue, which is critical for SARS-CoV-2 entry into cells.
- Findings revealed that lower ACE2 expression is linked to poorer cardio-metabolic health, such as type 2 diabetes and obesity, suggesting that reduced ACE2 may play a role in worsening COVID-19 outcomes among individuals with these health issues.
Common Genetic Variation and Age of Onset of Anorexia Nervosa.
Biol Psychiatry Glob Open Sci
October 2022
Article Synopsis
- This study explores the role of genetics in the age of onset of anorexia nervosa (AN) by analyzing data from a large genome-wide association study involving 9,335 cases and 31,981 control participants.
- Researchers found significant genetic variations linked to typical-onset AN and identified different genetic correlations for early-onset (before age 13) and typical-onset AN, indicating distinct biological influences.
- Results suggest a genetic relationship between the age at menarche and early-onset AN, implying that earlier menarche may increase the risk of developing AN at a younger age.
Many common illnesses, for reasons that have not been identified, differentially affect men and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren's syndrome affect nine times more women than men, whereas schizophrenia affects men with greater frequency and severity relative to women. All three illnesses have their strongest common genetic associations in the major histocompatibility complex (MHC) locus, an association that in SLE and Sjögren's syndrome has long been thought to arise from alleles of the human leukocyte antigen (HLA) genes at that locus.
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