Publications by authors named "Julia Boehling"
Article Synopsis
- Desmoplastic small round cell tumors (DSRCT) are aggressive pediatric sarcomas linked to the EWSR1::WT1 fusion oncogene, with poor survival rates of 15% to 25% due to ineffective standard treatments.
- The study demonstrated that targeting EWSR1::WT1 is crucial for DSRCT growth and identified its unique role in activating genes related to the cyclin D-CDK4/6-RB pathway.
- Treatment with the FDA-approved CDK4/6 inhibitor palbociclib effectively reduced DSRCT growth in models, suggesting a promising new therapeutic option for this challenging cancer.
The Never in Mitosis Gene A (NIMA)-related kinases (NEKs) are a group of serine/threonine kinases that are involved in a wide array of cellular processes including cell cycle regulation, DNA damage repair response (DDR), apoptosis, and microtubule organization. Recent studies have identified the involvement of NEK family members in various diseases such as autoimmune disorders, malignancies, and developmental defects. Despite the existing literature exemplifying the importance of the NEK family of kinases, this family of protein kinases remains understudied.
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