Publications by authors named "Julia B Berthet"
We hypothesized that human genes and disease-associated alleles might be systematically functionally annotated using morphological profiling of cDNA constructs, via a microscopy-based Cell Painting assay. Indeed, 50% of the 220 tested genes yielded detectable morphological profiles, which grouped into biologically meaningful gene clusters consistent with known functional annotation (e.g.
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- Thrombosis and biofouling in medical devices lead to high rates of complications, prompting the development of a new bioinspired coating for tubing and catheters.
- The coating, made of a flexible perfluorocarbon layer, effectively repels blood and prevents the formation of harmful biofilms on device surfaces.
- Successful tests in pigs show that this technology could allow medical devices to function without anticoagulants for extended periods, potentially minimizing the need for these medications and improving patient outcomes.
Here we describe a blood-cleansing device for sepsis therapy inspired by the spleen, which can continuously remove pathogens and toxins from blood without first identifying the infectious agent. Blood flowing from an infected individual is mixed with magnetic nanobeads coated with an engineered human opsonin--mannose-binding lectin (MBL)--that captures a broad range of pathogens and toxins without activating complement factors or coagulation. Magnets pull the opsonin-bound pathogens and toxins from the blood; the cleansed blood is then returned back to the individual.
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