Understanding Pseudomonas status among adults with cystic fibrosis: a real-world comparison of the Leeds criteria against clinicians' decision.

Pseudomonas aeruginosa status influences cystic fibrosis (CF) clinical management but no 'gold standard' definition exists. The Leeds criteria are commonly used but may lack sensitivity for chronic P. aeruginosa.

Does current reporting of lung function by the UK cystic fibrosis registry allow a fair comparison of adult centres?

Background: Outcome data for UK cystic fibrosis centres are publicly available in an annual report, which ranks centres by median FEV% predicted. We wished to assess whether there are differences in lung function outcomes between adult centres that might imply differing standards of care.

Methods: UK Registry data from 4761 subjects at 34 anonymised adult centres were used to calculate mean FEV% and rate of change of lung function for 2007-13.