Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia.

Late-life depression is associated with an increased risk for dementia but we have limited knowledge of the molecular mechanisms underlying this association. Here we investigated whether brain microRNAs, important posttranscriptional regulators of gene expression, contribute to this association. Late-life depressive symptoms were assessed annually in 300 participants of the Religious Orders Study and Rush Memory and Aging Project for a mean of 7 years.

Polymorphism in new thienothiophene-thiazolothiazole organic semiconductors.

The front cover artwork is provided by J. A. Schneider from D.

Polymorphism in new thienothiophene-thiazolothiazole organic semiconductors.

Charge transport in organic semiconductors is heavily influenced by their solid-state packing. To separate intermolecular packing effects from molecular electronic effects, we have synthesized two polymorphs of crystalline thienothiophene-thiazolothiazole trimers and studied them by DFT calculations, optical spectroscopy, single-crystal X-ray diffraction and charge-transport measurements in field-effect transistors. One polymorph was found to be a p-type semiconductor with a hole mobility of 3.

Brainstem aminergic nuclei and late-life depressive symptoms.

Importance: The neurobiologic basis of late-life depressive symptoms is not well understood.

Objective: To test the hypothesis that neurodegeneration and neuronal density in brainstem aminergic nuclei are related to late-life depressive symptoms. DESIGN, SETTING, PARTICIPANTS, AND EXPOSURE: Longitudinal clinicopathological cohort study at residences of participants in the Chicago, Illinois, metropolitan area.