Neuromodulators can promote nerve regeneration and accelerate functional recovery after peripheral nerve injury: A systematic review.

Peripheral nerve injuries (PNIs) are debilitating injuries that are also challenging to treat. With several different techniques being investigated to optimize nerve regeneration, we performed this systematic review aiming to evaluate and synthesize the available peer-reviewed literature regarding PNIs and the research that has been done to optimize peripheral nerve regeneration. Two research databases were searched, and abstracts were reviewed for relevance.

The Application of Hyaluronic Acid/Alginate Sheet to Flexor Pollicis Longus Tendon Repair to Prevent Adhesion Formation: A Second Look.

Soft tissue traumas with tendon lacerations are challenging injuries to manage. Repair of these tendon injuries can be complicated by adhesions postoperatively, limiting patient function and satisfaction. Biologic agents have been developed to optimize tendon gliding after repair and can be used as adjuncts.

Patient Factors, Donor Age, and Graft Storage Duration Affect Osteochondral Allograft Outcomes in Knees with or without Comorbidities.

Limited data exists defining preoperative variables that affect outcomes after osteochondral allograft transplantation (OAT) in the knee. In this retrospective study, we examined 75 patients who underwent OAT for large (≥2 cm) grade IV cartilage defects in the femoral condyle. Patient variables evaluated included the following: smoking, workers compensation, body mass index (BMI), pre-injury activity level, number, and the type of co-morbidities in the operated knee, lesion location and number of grafts placed.

Ketorolac administration does not delay early fracture healing in a juvenile rat model: a pilot study.

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective at controlling pain in children, especially in the treatment of fractures. Adult animal and adult clinical studies demonstrate conflicting evidence for the inhibitory relationship between NSAIDs and fracture healing. Published pediatric orthopaedic clinical studies do not demonstrate an inhibitory effect of ketorolac on bone healing.