Publications by authors named "Julia A Krupinova"
Introduction: Until recently no major epidemiological research of primary hyperparathyroidism (PHPT) has been conducted in the Russian Federation, this led to the creation of the Russian online registry. The objective of this study is to estimate the clinical and biochemical profile, classical and non-classical complications, surgical intervention and medical therapy of the patients with different forms of PHPT in the Russian Federation.
Materials And Methods: The cross-sectional, observational, continuous study was conducted at the Endocrinology Research Centre (Moscow).
Article Synopsis
- The study investigates the relationship between primary hyperparathyroidism (PHPT) and metabolic syndrome components in young patients, highlighting significant rates of insulin resistance and excessive visceral fat.
- A comprehensive assessment before and after parathyroid surgery showed patients had higher triglycerides and insulin levels, but surgery did not lead to significant changes in lipid profiles or body composition.
- The findings suggest that PHPT is linked to insulin resistance, a major risk factor for metabolic disorders, and that surgical intervention may offer some improvements in carbohydrate and purine metabolism.
Background And Objective: Preoperative diagnosis of parathyroid carcinoma (PC) is critical for the determination of the scope of surgical intervention. Nowadays, specific diagnostic markers for differentiation of PC and benign tumors are unknown, and less than half of patients with PC undergo necessary surgery. The aim of this study was to develop the instrument for preoperative diagnosis of PC.
View Article and Find Full Text PDFIntroduction: Chronic hypoparathyroidism is a relatively rare disease associated with multicomponent medical therapy and various complications. The analysis of large databases of patients with chronic hypoparathyroidism is a necessary tool to enhance quality of medical care, as well as to determine the optimal clinical and therapeutic approaches, and prognostic markers of the disease.
The Aim: of this study is to estimate the clinical and biochemical profile, long-term complications, medical therapy and disease control of the patients with chronic postsurgical and non-surgical hypoparathyroidism.