Publications by authors named "Julia A Klaips"
Biochim Biophys Acta
September 2014
Article Synopsis
- Antimicrobial peptides like hipposin, derived from histones, are being explored as alternatives to traditional antibiotics, particularly for their unique antibacterial mechanisms.
- Hipposin's antibacterial action involves promoting membrane permeabilization, especially through its N-terminal domain, while lacking this sequence makes it behave more like buforin II, which affects intracellular structures.
- The study identifies the C-terminal portion of hipposin as HipC, which can penetrate cells without exerting antimicrobial effects, highlighting its potential for developing chimeric peptides with varied antimicrobial properties.
