Publications by authors named "Jule Gerlach"
Article Synopsis
- * Conditional knockout studies in PARKIN-deficient mice reveal that loss of PARKIN does not impact mitochondrial functions such as oxidative phosphorylation or worsen brain defects, challenging previous assumptions about its importance.
- * A case study of a patient with PARKIN deficiency shows no impairment in mitochondrial function, suggesting that PARKIN is not necessary for maintaining OXPHOS activity in adult tissues.
In cells, proteins encoded by the same gene do not all behave uniformly but engage in functional subpopulations induced by spatial or temporal segregation. While conventional microscopy has limitations in revealing such spatial and temporal diversity, single-molecule tracking (SMT) microscopy circumvented this problem and allows for high-resolution imaging and quantification of dynamic single-molecule properties. Particularly in the nucleus, SMT has identified specific DNA residence times of transcription factors (TFs), DNA-bound TF fractions and positions of transcriptional hot-spots upon cell stimulation.
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