Publications by authors named "Jule Dingfelder"
Background: Corroborating evidence for use of hypothermic oxygenated machine perfusion (HOPE) prior to orthotopic liver transplantation (OLT) suggests a beneficial effect in regards to biliary complications. Here, we aim to evaluate whether perfusion via portal vein alone (sHOPE) or via additional perfusion of the hepatic artery (dHOPE) have diverging impact on outcomes after OLT when compared to use of static cold storage (SCS).
Methods: Consecutive patients undergoing OLT at Medical University of Vienna (2018 to 2023) were retrospectively analyzed.
Induction therapy with depleting antibodies in the setting of liver transplantation (LT) is discussed controversially to this day. The rabbit antithymocyteglobulin (ATG) Thymoglobulin (rATG) was introduced as early as 1984 and was frequently used as a standard regime for induction therapy after LT. There are no public reports characterizing Grafalon (ATG-F), a novel ATG, as an induction agent after LT.
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- A new study evaluated long-term outcomes of liver transplants from donors treated with hypothermic oxygenated machine perfusion (HOPE) across 22 European centers, involving 1,202 transplant cases from 2012 to 2021.
- The study showed high 1-, 3-, and 5-year death-censored graft survival rates for both donation after brain death (DBD) and donation after circulatory death (DCD), with low rates of primary non-function (PNF) and ischaemic cholangiopathy (IC).
- The findings indicate that HOPE treatment effectively improves liver transplant outcomes, regardless of the donor's risk profile, and supports its incorporation into routine clinical practice.
To date, caval sparing (CS) and total caval replacement (TCR) for recipient hepatectomy in liver transplantation (LT) have been compared only in terms of surgical morbidity. Nonetheless, the CS technique is inherently associated with an increased manipulation of the native liver and later exclusion of the venous outflow, which may increase the risk of intraoperative shedding of tumor cells when LT is performed for HCC. A multicenter, retrospective study was performed to assess the impact of recipient hepatectomy (CS vs.
View Article and Find Full Text PDFIn recent years, significant progress has been made in the field of liver machine perfusion. Many large transplant centers have implemented machine perfusion strategies in their clinical routine. Normothermic machine perfusion (NMP) is primarily used to determine the quality of extended criteria donor (ECD) organs and for logistical reasons.
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