Publications by authors named "Jukun Yang"
Article Synopsis
- Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer, making early detection and diagnosis essential for improving patient survival rates.
- The study developed a biosensor that combines electrochemiluminescence technology with DNA sensing to accurately diagnose TNBC using microRNAs as biomarkers.
- The biosensor demonstrated high sensitivity and effectiveness in detecting specific microRNAs related to TNBC, with potential applications for clinical diagnosis and personalized treatment strategies.
Article Synopsis
- Inflammation can worsen cancer progression in tumors like osteosarcoma by promoting metastasis, and current diagnostic methods struggle to accurately differentiate between inflammation and tumor activities.* -
- A new "hedgehog ball"-shaped nanoprobe, FeO@Au-pep-CQDs, was created to improve early detection of caspase-1, a significant inflammation marker, using simultaneous fluorescence and electrochemiluminescence techniques.* -
- Experimental results showed the nanoprobe's high sensitivity and reliability in detecting caspase-1, achieving low detection limits and good recovery rates, while also allowing for in vivo bioimaging to visualize biological processes effectively.*
Pancreatic ductal adenocarcinoma (PDAC) poses significant diagnostic challenges due to its asymptomatic nature in its early stages, low specificity of conventional in vitro assays, and limited efficacy of surgical interventions. However, clinical specificity of the current serum biomarkers is suboptimal, leading to diagnostic inaccuracies and oversights. Therefore, this study introduced a novel dual-target electrochemiluminescence (ECL) biosensor to address these critical issues.
View Article and Find Full Text PDFCancer surgery remains a mainstay in clinical treatment. However, the efficacy of subsequent therapies largely depends on the precise evaluation of postoperative prognoses, underscoring the critical need for a comprehensive and accurate assessment of surgical outcomes. Nanoprobes targeting tumors offer a promising solution for visual prognostic assessment.
View Article and Find Full Text PDFMatrix metalloproteinase 2 (MMP-2) is a crucial biomarker of tumor growth, invasion and metastasis. In the present study, a core-satellite magnetic-fluorescent-plasmonic nanosensor (FMNS@Au) was constructed through biological self-assembly to generate localized SERS "hot spots" and an efficient FRET system for the sensitive determination of MMP-2 activity in a SERS-fluorescence dual-mode assay. In this hybrid nanosensor, a biotin-labeled peptide containing a specific MMP-2 substrate (PLGVR) was employed as a bridge for the assembly of gold nanoparticles (AuNPs) and avidin functionalized fluorescent-magnetic nanospheres (FMNS).
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