Publications by authors named "Jukka Parantainen"
The coagulation cascade and fibrinolysis have links with neuroinflammation and increased activation of the coagulation system has been reported in MS patients. We quantified levels of D-dimer, tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and the bioactivity of bacterial lipopolysaccharide (LPS) in cerebrospinal fluid (CSF) and plasma from newly diagnosed untreated MS patients and controls. These molecules showed multiple correlations with each other as well as with age, HLA-DRB1*15:01, body-mass-index and CSF IgG.
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- Mutations in genes involved in innate immune responses can lead to severe autoinflammatory diseases, causing a dangerous overactivation of inflammasome pathways and type I interferon responses.* -
- Research identifies six families with members suffering from necrotizing fasciitis linked to a specific genetic variant (NFKB1) that disrupts immune regulation in macrophages.* -
- Patients showed improvement with anti-inflammatory treatments, suggesting that focusing on blocking IL-1β or IFN-I signaling could offer new therapeutic options.*
Objectives: The NLRP3 inflammasome plays a key role in arterial wall inflammation. In this study, we elucidated the role of serum lipoproteins in the regulation of NLRP3 inflammasome activation by serum amyloid A (SAA) and other inflammasome activators.
Methods: The effect of lipoproteins on the NLRP3 inflammasome activation was studied in primary human macrophages and THP-1 macrophages.
Objectives: To examine the clinical risk factors and complications of shoulder dystocia today and to evaluate ultrasound methods predicting it.
Study Design: Retrospective, matched case-control study at a University Hospital with 5000 annual deliveries. The study population consisted of 152 deliveries complicated by shoulder dystocia over a period of 8.