Publications by authors named "Jui-Chang Tasi"
Article Synopsis
- O(6)-Methylguanine-DNA methyltransferase (MGMT) is crucial for DNA repair and affects how cancers respond to alkylating agents like temozolomide, especially in brain metastases.
- This study analyzed the expression and methylation of MGMT in 86 lung cancer brain metastases, finding significantly higher MGMT expression in metastases (83%) than in primary tumors (50%).
- Patients with positive MGMT expression in brain metastases experienced much longer overall survival (16.5 months) compared to those with negative expression (3.5 months), indicating MGMT's potential as a prognostic marker.
