Publications by authors named "Jui Chien Hung"
Article Synopsis
- Rodent models of arterial injury have been essential for understanding restenosis and advancing endovascular treatments for heart disease, with common models being mouse wire and rat balloon injuries.
- While these standard models have provided valuable insights, they also present challenges like technical difficulty and disruption of blood flow, prompting the need for complementary injury models.
- The study introduces a new surgical model for rats that induces vessel injury without permanent artery ligation, demonstrating similar neointimal hyperplasia and endothelial recovery as existing models, while better mimicking the physiological conditions relevant to vascular injury.
Article Synopsis
- Periosteum is a vital, blood-rich membrane that covers bones, crucial for healing and surgery recovery.
- A new ex vivo perfusion bioreactor was developed to keep periosteal tissues alive and metabolically active, simulating natural conditions by providing nutrients and oxygen.
- The study demonstrates that this method can preserve periosteum for nearly four weeks, offering potential for advanced bone repair techniques using transplanted periosteum.
Access to lab-grown fully functional blood vessels would provide an invaluable resource to vascular medicine. The complex architecture and cellular makeup of native vessels, however, makes this extremely challenging to reproduce. Bioreactor systems have helped advanced research in this area by replicating many of the physiological conditions necessary for full-scale tissue growth outside of the body.
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