Publications by authors named "Juhye Yim"
Article Synopsis
- TAM-family tyrosine kinases (TYRO3, AXL, and MERTK) are important in cancer research, and blocking MERTK was helpful in fighting a type of leukemia called B-ALL.
- Research showed that reducing MERTK helped increase special immune cells, which is good for fighting leukemia, especially in young patients.
- The study suggests that targeting MERTK and TYRO3 could be new ways to treat leukemia by using the body's immune system better.
Cancer cells utilize epigenetic alterations to acquire autonomous capabilities for tumor maintenance. Here, we show that pancreatic ductal adenocarcinoma (PDA) cells utilize super-enhancers (SEs) to activate the transcription factor EVI1 (ecotropic viral integration site 1) gene, resulting in activation of an EVI1-dependent transcription program conferring PDA tumorigenesis. Our data indicate that SE is the vital -acting element to maintain aberrant EVI1 transcription in PDA cells.
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