Publications by authors named "Juhua Zhao"
Introduction: Prior research has explored the relationship between inflammatory skin disorders and breast cancer (BC), yet the causality of this association remains uncertain.
Methods: Utilizing a bidirectional two-sample Mendelian randomization (MR) approach, this study aimed to elucidate the causal dynamics between various inflammatory skin conditions-namely acne, atopic dermatitis, psoriasis vulgaris, urticaria, and rosacea-and BC. Genetic variants implicated in these disorders were sourced from comprehensive genome-wide association studies representative of European ancestry.
Background: Dentin matrix protein 1 (DMP1) is central to matrix mineralization. Clarification of the function of DMP1 is crucial to understanding normal bone formation and pathological calcification. The tissue-nonspecific alkaline phosphatase (TNAP) -progressive ankylosing enzyme (ANK) -extracellular nucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) axis induces deposition of hydroxyapatite (HA) and pyrophosphate dehydrate (CPPD) by regulating pyrophosphate (PPi).
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- Oncogenes, like the Holliday Junction Recognition Protein (HJURP), play a significant role in cancer development, acting as a chaperone for histone H3 and influencing nucleosome composition.
- HJURP is found on chromosome 2q37.1 and is crucial for assembling centromere structures, with its dysfunction linked to tumorigenesis and poor cancer prognosis.
- Research indicates that HJURP is often overexpressed in various cancers, promoting cell proliferation and invasiveness, making it a potential target for innovative cancer therapies.