Publications by authors named "Juho Rantakokko"

Article Synopsis
  • Spinal fusion surgery results in severe pain, and while strong opioids like oxycodone are commonly used, they can have side effects; this study explored the use of S-ketamine as an adjunct to help reduce opioid consumption.
  • In a randomized, double-blind trial with 107 patients, different doses of S-ketamine were compared to placebo in conjunction with oxycodone patient-controlled analgesia (PCA) following major lumbar spinal fusion surgery.
  • Results showed that the highest dose of 0.75 mg/ml S-ketamine led to a 25% reduction in cumulative oxycodone use and improved pain intensity at rest without increasing adverse effects compared to lower doses or oxycodone alone.
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Purpose: Positive spinal sagittal alignment is known to correlate with pain and disability. The association between lumbar spinal stenosis and spinal sagittal alignment is less known, as is the effect of lumbar decompressive surgery on the change in that alignment. The objective was to study the evidence on the effect of lumbar decompressive surgery on sagittal spinopelvic alignment.

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Background: Previous studies have suggested that variation in results of lumbar discectomy depends on careful selection of patients. Numerous factors have been suggested to explain this variation with no direct examinations on this issue. The objective was to examine the use of pain medication before and after lumbar discectomy in patients with back pain.

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Background And Purpose: Concern has emerged about local soft-tissue reactions after hip resurfacing arthroplasty (HRA). The Birmingham Hip Resurfacing (BHR) was the most commonly used HRA device at our institution. We assessed the prevalence and risk factors for adverse reaction to metal debris (ARMD) with this device.

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Background And Purpose: The clinical findings of adverse reaction to metal debris (ARMD) following large-diameter-head metal-on-metal total hip arthroplasty (LDH MoM THA) may include periarticular fluid collections, soft tissue masses, and gluteal muscle necrosis. The ReCap-M2a-Magnum LDH MoM THA was the most commonly used hip device at our institution from 2005 to 2012. We assessed the prevalence of and risk factors for ARMD with this device.

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Most commonly, shoulder instability results from a traumatic dislocation of the shoulder joint, usually happening to men under the age of 30. The first uncomplicated dislocation is treated conservatively. Instability refers to symptomatic instability of the shoulder joint, i.

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Purpose. Biceps long head pathology is often associated with rotator cuff tears. The aim of this study was to determine the effect of possible associated biceps procedure on the treatment outcome in rotator cuff repair.

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A prospective long-term follow-up study of bioactive glass (BAG)-S53P4 and autogenous bone (AB) used as bone graft substitutes for posterolateral spondylodesis in treatment of degenerative spondylolisthesis during 1996 to 1998 was conducted. The surgical procedure was a standardized instrumented posterolateral fusion that used USS/VAS. BAG was implanted on the left side of the fusion bed and AB on the right side.

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Cathepsin K is a major osteoclastic protease. We have recently shown that overexpression of mouse cathepsin K gene in transgenic UTU17 mouse model results in high turnover osteopenia of metaphyseal trabecular bone at the age of 7 months. The present report extends these studies to a systematic analysis of cortical bone in growing and adult mice overexpressing cathepsin K.

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