Physicochemical stability of high-concentration cefuroxime aqueous injection reconstituted by a centralised intravenous additive service.

Objectives: Hospital pharmacies provide centralised intravenous additive services (CIVAS), such as antibiotic reconstitution. The aim of this study was to demonstrate the physicochemical stability of high-concentration cefuroxime sodium in aqueous injections, which is mandatory for the centralised preparation of products with automation.

Methods: The physicochemical stability of three high-concentration injections (1.