Publications by authors named "Juhao Zeng"
Background: Sepsis is an uncontrolled inflammatory response to infection and is closely associated with the occurrence of acute respiratory distress syndrome (ARDS). Low tidal volume lung ventilation and permissive hypercapnia is a recognized therapy for ARDS. However, whether permissive hypercapnia aggravates sepsis-associated encephalopathy (SAE) remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- Cerebral ischemia leads to significant brain injury, with the blood-brain barrier (BBB) playing a critical role in this process, making its regulation during ischemia essential to understand.
- In this study, both in vitro and in vivo models were used to examine the effects of PD-1 overexpression and inhibition on microglia and BBB permeability, employing various biochemical techniques to measure inflammation and brain injury.
- Results showed that PD-1 overexpression shifted microglia from an inflammatory M1 state to a protective M2 state, reducing BBB permeability and brain damage, suggesting a potential therapeutic role for PD-1 in cerebral ischemia.
[Predictive value of sepsis-induced coagulopathy score on 30-day mortality in septic patients].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
December 2022
Objective: To evaluate the predictive effect of sepsis-induced coagulopathy (SIC) score level on the prognosis of septic patients under sepsis 3.0 criteria.
Methods: A retrospective single-center observational study was conducted on the septic patients admitted to the department of critical care medicine and the department of emergency in Guangdong Provincial People's Hospital from August 2016 to July 2021.
Sepsis can cause sepsis-associated encephalopathy (SAE), but whether SAE was induced or exacerbated by ferroptosis remains unknown. In this study, the rat sepsis model was constructed using the cecal ligation and puncture method. The blood-brain barrier (BBB) permeability was measured by Evans blue dye (EBD) in vivo.
View Article and Find Full Text PDF[β1 receptor blocker decreases the myocardial inflammation in the sepsis adult rats through inhibition of TLR4/NF-ΚB signaling pathway].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
February 2019
Objective: To explore whether β1 receptor blocker could decrease the myocardial inflammation through the Toll-like receptor 4/nuclear factor-ΚB (TLR4/NF-ΚB) signaling pathway in the sepsis adult rats.
Methods: Sixty male Wistar rats (250-300 g) aged 3 months old were allocated to four groups by random number table (n = 15): sham operation group (S group), sepsis model group (CLP group), β1 receptor blocker esmolol intervention group (ES group), and inhibitor of the TLR4 E5564 intervention group (E5564 group). The rat sepsis model was established by cecal ligation and puncture (CLP); S group of rats underwent only an incision.
[Esmolol improves clinical outcome and tissue oxygen metabolism in patients with septic shock through controlling heart rate].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
September 2015
Objective: To investigate whether esmolol could improve clinical outcome and tissue oxygen metabolism by controlling heart rate (HR) in patients with septic shock.
Methods: A single-center double-blinded randomized controlled trial was conducted. The patients suffering from septic shock received 6-hour early goal directed herapy (EGDT) with pulmonary artery wedge pressure ≥ 12 mmHg (1 mmHg = 0.