Publications by authors named "Jugal B Joshi"
Article Synopsis
- Id4 is identified as a tumor suppressor in prostate cancer, with a study exploring its impact on mouse prostate development at various ages.
- Mice lacking Id4 exhibited smaller prostates and altered tissue structures, including lesions resembling prostatic intraepithelial neoplasia (PIN) at six months.
- The study found changes in specific gene expressions related to stem cell markers and prostate differentiation, suggesting that loss of Id4 disrupts normal prostate development and promotes conditions associated with cancer.
Castration-resistant prostate cancer (CRPC) is the emergence of prostate cancer cells that have adapted to the androgen-depleted environment of the prostate. In recent years, targeting multiple chaperones and co-chaperones (e.g.
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