Inverted U-shape association between urine equol levels and cancer: a national population-based cross-sectional study.

Equol, a naturally occurring phytoestrogen derived from the fermentation of soy and soy-based products by gut bacteria, is recognized for its diverse health benefits. While there is speculation about its association with cancer prevention, the scientific community has yet to reach a consensus due to the variability in research findings. Our study aims to shed light on this topic by examining the correlation between urine equol concentrations and the cancer risk among the American population.

Construction and verification of a prognostic model for bladder cancer based on disulfidptosis-related angiogenesis genes.

Background: Bladder cancer (BLCA) is the most common malignancy of the urinary system and one of the most common cancers worldwide. This study seeks to examine the influence of angiogenesis-related genes (ARGs) linked to disulfidptosis on BLCA patients and to formulate a prognostic model for evaluating their prognosis and response to immunotherapy.

Methods: This study used sequencing data of BLCA in the Cancer Genome Atlas (TCGA) database.