Publications by authors named "Jueyi Mao"
Article Synopsis
- - Microglia are specialized immune cells in the central nervous system that help maintain health and respond to injury or disease, playing a key role in neuroinflammation related to neurodegenerative diseases and tumors.
- - Research suggests that extracellular vesicles can facilitate communication between cells by transporting molecules, which is important for microglial signaling in the nervous system.
- - The text emphasizes the need to understand how microglia and extracellular vesicles contribute to brain health and disease progression, potentially paving the way for new therapeutic approaches that do not involve direct cell intervention.
Article Synopsis
- * EVs significantly influence diseases, including tumors and autoimmune disorders, by altering immune responses and potentially worsening disease progression.
- * The paper aims to review how EVs impact immune cell numbers and functions, and the release of immune-related molecules across various diseases, highlighting their negative effects to enhance management strategies for immune disorders.
Article Synopsis
- Autoimmune diseases happen when the body's immune system mistakenly attacks its own healthy cells, causing damage and inflammation.
- Omega-3 fatty acids, found in foods like fish, might help reduce this inflammation, but scientists aren't sure how effective they are for different autoimmune diseases.
- A study analyzed 21 previous studies and found that omega-3s seem to help with some autoimmune diseases like rheumatoid arthritis and lupus but didn’t provide clear evidence for their effects on others like psoriasis and type 1 diabetes.
The immune system, functioning as the body's "defense army", plays a role in surveillance, defense. Any disruptions in immune system can lead to the development of immune-related diseases. Extensive researches have demonstrated the crucial immunoregulatory role of mesenchymal stem cells (MSCs) in these diseases.
View Article and Find Full Text PDFBackground: Human umbilical cord mesenchymal stem cells-derived extracellular vesicles (hUCMSC-EVs) have potent immunomodulatory properties similar to parent cells. This study investigated the therapeutic effects and immunomodulatory mechanisms of hUCMSC-EVs in an experimental lupus nephritis model.
Methods: The hUCMSC-EVs were isolated by using differential ultracentrifugation.
Background: Due to its highly reabsorptive function, the kidney is a mitochondria-dependent organ. Research on the association between mitochondria and kidney disease has always been a serious focus of researchers, with many publications. Bibliometrics is a secondary analysis of published literature that extracts relevant information to gain insights into hotspots and trends in the field.
View Article and Find Full Text PDFExtracellular vesicles (EVs) are lipid containers that are actively released by cells and contain complex molecular cargoes. These cargoes include abundant material such as genomes and proteins from cells of origin. They are involved in intercellular communication and various pathological processes, showing excellent potential for diagnosing and treating diseases.
View Article and Find Full Text PDFBackground: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by isolated thrombocytopenia. Recently, the pathophysiology and novel drugs of ITP have been the focus of researchers with plenty of publications emerging. Bibliometrics is the process of extracting measurable data through statistical analysis of published research studies to provide an insight into the trends and hotspots.
View Article and Find Full Text PDFImmune thrombocytopenia (ITP) is an acquired autoimmune disease involving a variety of immune cells and factors. Despite being a benign disease, it is still considered incurable due to its complex pathogenesis. Mesenchymal stem cells (MSCs), with low immunogenicity, pluripotent differentiation, and immunomodulatory ability, are widely used in a variety of autoimmune diseases.
View Article and Find Full Text PDFKidney disease is a serious hazard to human health. Acute or chronic renal disease will have a significant negative impact on the body's metabolism. The involvement of mitochondria in renal illness has received a lot of interest as research on kidney disease has advanced.
View Article and Find Full Text PDFArticle Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by improper immune responses leading to multi-organ damage, largely due to dysfunctional T cells and excessive autoantibodies from B cells.
- Recent studies suggest that human umbilical cord mesenchymal stem cells (hUCMSCs) and their extracellular vesicles (hUCMSC-EVs) may help regulate these immune responses in SLE, though the role of MSC-EVs is not fully understood.
- In experiments using a mouse model of SLE, both hUCMSCs and hUCMSC-EVs were found to inhibit certain T cell activities while promoting others, indicating that hUCMSC-EVs could serve as potential therapeutic agents in
Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs and systems, featuring recurring flare-ups and the presence of autoantibodies.
- The disease's complexity involves genetic factors and immune dysregulation, leading to imbalances in T and B cell activities and consequent tissue damage.
- This review emphasizes the role of B1 cells, an innate-like immune subset, in SLE, aiming to uncover their mechanisms for potential therapeutic advancements.