Publications by authors named "Jueun C Kim"
Introduction: Plasma Aβ42/40 ratio can help predict amyloid PET status, but its clinical utility in Alzheimer's disease (AD) assessment is unclear.
Methods: Aβ42/40 ratio was measured by LC-MS/MS for 250 specimens with associated amyloid PET imaging, diagnosis, and demographic data, and for 6,192 consecutive clinical specimens submitted for Aβ42/40 testing.
Results: High diagnostic sensitivity and negative predictive value (NPV) for Aβ-PET positivity were observed, consistent with the clinical performance of other plasma LC-MS/MS assays, but with greater separation between Aβ42/40 values for individuals with positive vs.
Article Synopsis
- Early detection of Alzheimer's disease is crucial, with beta-amyloid levels and the Aβ42/40 ratio being key indicators of the disease's progression.
- Researchers developed and validated a high-throughput LC-MS/MS assay to measure Aβ40 and Aβ42 peptides in plasma, along with identifying ApoE proteotypes, which serve as a substitute for genetic testing.
- The assays showed high precision, accuracy, and sensitivity, adhering to Clinical and Laboratory Standards Institute (CLSI) guidelines, and effectively correlated proteotype results with genetic information.
Introduction: Plasma Aβ42/40 ratio can be used to help predict amyloid PET status, but its clinical utility in Alzheimer's disease (AD) assessment is unclear.
Methods: Aβ42/40 ratio was measured by LC-MS/MS in 250 specimens with associated amyloid PET imaging, diagnosis, and demographic data, and 6,192 consecutive clinical specimens submitted for Aβ42/40 testing.
Results: High diagnostic sensitivity and negative predictive value (NPV) for Aβ-PET positivity were observed, consistent with the clinical performance of other plasma LC-MS/MS assays, but with greater separation between Aβ42/40 values for individuals with positive vs negative Aβ-PET results.