Publications by authors named "Judyta Karolina Juranek"
Article Synopsis
- - Neuropathy, a common issue for diabetes patients, is linked to high blood sugar levels causing proteins to undergo non-enzymatic glycation, which activates the RAGE receptor and may contribute to nerve damage.
- - The cytoskeletal protein DIAPH1 interacts with RAGE and may exacerbate diabetic neuropathy if dysfunctional, with both RAGE and DIAPH1 being present in nerve tissues from diabetic models.
- - Elevated blood sugar not only increases advanced glycation end products that activate RAGE but also leads to a pro-inflammatory environment and disruption of cellular signaling, potentially impacting nerve structure and function.
Signal transduction and neurotransmitter release in the vertebrate central nervous system are confined to the structurally complex presynaptic electron dense projections called "active zones." Although the nature of these projections remains a mystery, genetic and biochemical work has provided evidence for the active zone (AZ) associated proteins i.e.
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