Association Between Serum Thyrotropin and Cancer Recurrence in Differentiated Thyroid Cancer: A Population-Based Retrospective Cohort Study.

Levothyroxine to suppress thyrotropin (TSH) to <0.5 mIU/L following thyroidectomy in differentiated thyroid cancer (DTC) may reduce recurrence in higher-risk DTC. However, there is limited evidence to support guideline recommendations to maintain TSH in the low-normal range of 0.

Risk of Adverse Cardiovascular Outcomes in Differentiated Thyroid Cancer Survivors: A Systematic Review and Meta-Analysis.

Long-term cardiovascular (CV) risk is a concern for differentiated thyroid cancer (DTC) survivors. We performed a systematic review and meta-analysis evaluating the risks of CV mortality and morbidity in DTC survivors compared with the general population. Respective meta-analyses were conducted for data that were adjusted for relevant confounders and crude data.

Association between diabetes, obesity, aging, and cancer: review of recent literature.

Rates of obesity and diabetes have risen significantly in recent years and are projected to increase even further in the coming decades. Obesity and diabetes are associated with increased risk of certain tumours, with the strongest relationships demonstrated for colorectal, post-menopausal breast, and endometrial cancer. Another important risk factor for cancer development is aging.

Impact of diabetes on colorectal cancer stage and mortality risk: a population-based cohort study.

Aims/hypothesis: Diabetes is associated with an increased incidence of colorectal cancer (CRC). There exists conflicting evidence regarding the impact of diabetes on CRC-specific mortality (herein also referred to as cancer-specific mortality). The objectives of this study were to determine whether diabetes is associated with a more advanced CRC stage at diagnosis and with higher all-cause and cancer-specific mortality.

Variations in RBC and frozen plasma utilization rates across 62 Ontario community hospitals.

Background: Recent province-wide audits of frozen plasma (FP) and RBC use in Ontario showed a high rate of inappropriate transfusions.

Study Design And Methods: This was a retrospective, ecological study to determine variations in RBC and FP utilization rates across Ontario community hospitals between 2012 and 2017. Annual utilization rates were reported using descriptive statistics.

Survival rates of biological therapies for psoriasis treatment in real-world clinical practice: A Canadian multicentre retrospective study.

Background/objectives: Data on biologic drug survival in real-world psoriasis treatment are limited. There is a need to evaluate long-term trends of biologic use outside the realm of clinical trials.

Methods: A multicentre chart review was conducted with patients' data from September 2005 to September 2014.

Risk of Malignancy in Dermatomyositis and Polymyositis.

Background: There is variation in the risk of malignancy in dermatomyositis (DM) and polymyositis (PM) in the existing literature.

Objective: To conduct a meta-analysis to estimate the risk of malignancy in DM and PM as compared with the general population.

Methods: Medline and Embase Database abstracts were searched through August 2014 using the search terms myositis, neoplasms, and paraneoplastic syndromes.

Support systems of women with epilepsy in pregnancy: A retrospective needs assessment.

Purpose: To explore support systems for women with epilepsy (WWE) during pregnancy.

Methods: Audio-recorded, transcribed, semi-structured telephone interviews with WWE in pregnancy and following childbirth were coded using descriptive thematic analysis.

Results: Twelve women with epilepsy aged 21-37 years who received care during pregnancy in our epilepsy clinic from 2010 to 2013 were interviewed.

Telemedicine in Parkinson's disease: A patient perspective at a tertiary care centre.

Introduction: To overcome travel distance and lack of local expertise, telemedicine programs have been implemented and are still pilot programs in many jurisdictions. Patient perspectives remain poorly understood. In the largest study to date, we examined user satisfaction and predictors of patient choice to use telemedicine among Parkinson's Disease (PD) patients in the context of a well-developed telemedicine system.

Plasma apolipoprotein A1 as a biomarker for Parkinson disease.

Objective: To identify plasma-based biomarkers for Parkinson disease (PD) risk.

Methods: In a discovery cohort of 152 PD patients, plasma levels of 96 proteins were measured by multiplex immunoassay; proteins associated with age at PD onset were identified by linear regression. Findings from discovery screening were then assessed in a second cohort of 187 PD patients, using a different technique.

Effects of diurnal variation on the Test of Variables of Attention performance in young adults with attention-deficit/hyperactivity disorder.

The Test of Variables of Attention (TOVA) is a continuous performance test that assesses attention, impulsivity, and processing speed. Continuous performance tests are used in the assessment of attention-deficit/hyperactivity disorder (ADHD) in children and adults. TOVA norms are based on a morning administration, and any TOVA administered after 1:00 p.