Publications by authors named "Judy Franco"
Article Synopsis
- Chagas disease, caused by Trypanosoma cruzi, is prevalent in south Texas, posing a risk to outdoor-housed nonhuman primates, particularly cynomolgus macaques, due to exposure to insect vectors and wild mammalian reservoirs.
- A study found an 8.5% prevalence of T. cruzi in cynomolgus macaques, with 23% of seropositive individuals testing negative for the parasite via real-time PCR, indicating potential discrepancies in diagnostic methods and suggesting infectious stages may not always be visible in tissues.
- The presence of T. cruzi and associated autoimmune responses could complicate cardiac evaluations in preclinical studies, emphasizing the need for screening outdoor-housed primates
Purpose: This study assesses the impact of rat multidrug resistance-associated protein 2 (Mrp2) on the biliary excretion and oral absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats (EHBR).
Methods: To assess Mrp2-mediated biliary excretion, rats received a 2-h intravenous infusion of furosemide, probenecid, or methotrexate. Blood and bile samples were collected at specified intervals.