Publications by authors named "Judith-Mira Pohl"
Article Synopsis
- Enterohaemorrhagic E. coli can cause severe epidemics with high mortality rates due to its ability to produce shiga toxin, leading to kidney damage and hemolytic uremic syndrome.
- The study focused on how tissue-resident macrophages in the kidneys react during this disease, demonstrating that their activation contributes to inflammation and disease severity through the production of TNFα.
- By depleting macrophages, researchers found reduced inflammation and neutrophil recruitment, indicating that targeting these macrophages could be a potential therapy to lessen kidney damage caused by the infection.
The hemolytic uremic syndrome (HUS) is a life-threatening disease of the kidney that is induced by shiga toxin-producing E.coli. Major changes in the monocytic compartment and in CCR2-binding chemokines have been observed.
View Article and Find Full Text PDFObjective: Postoperative ileus (POI), the most frequent complication after intestinal surgery, depends on dendritic cells (DCs) and macrophages. Here, we have investigated the mechanism that activates these cells and the contribution of the intestinal microbiota for POI induction.
Design: POI was induced by manipulating the intestine of mice, which selectively lack DCs, monocytes or macrophages.
The phagocytes of the innate immune system, macrophages and neutrophils, contribute to antibacterial defense, but their functional specialization and cooperation is unclear. Here, we report that three distinct phagocyte subsets play highly coordinated roles in bacterial urinary tract infection. Ly6C(-) macrophages acted as tissue-resident sentinels that attracted circulating neutrophils and Ly6C(+) macrophages.
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