Publications by authors named "Judith Vinaixa Forner"
We show the ability of LACTB to function as a tumor suppressor in ovarian cancer through down-regulation of Slug and induction of differentiation.
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- Epithelial-mesenchymal transition (EMT) allows cancer cells to move and behave like stem cells, contributing to tumor progression, particularly in ovarian cancer.
- The study reveals that the mitochondrial protein LACTB acts as a tumor suppressor and is often found at lower levels in ovarian cancer cells and patient tissues.
- By reintroducing LACTB, researchers found it hindered cancer cell growth and promoted differentiation, which reduces the stemness of the cells through inhibiting the EMT process and down-regulating key transcription factors.
Background: LACTB was recently identified as a mitochondrial tumour suppressor that negatively affects cancer cell proliferation by inducing cell death and/or differentiation, depending on the cell type and tissue. However, the detailed mechanism underlying the LACTB-induced cancer cell death is largely unknown.
Methods: We used cell-based, either in 2D or 3D conditions, and in vivo experiments to understand the LACTB mechanisms.