Publications by authors named "Judith Syrkin-Nikolau"
In the central nervous system injury induces cellular reprogramming and progenitor proliferation, but the molecular mechanisms that limit regeneration and prevent tumorigenesis are not completely understood. We previously described a zebrafish optic pathway tumor model in which transgenic Tg(flk1:RFP)is18/+ adults develop nonmalignant retinal tumors. Key pathways driving injury-induced glial reprogramming and regeneration contributed to tumor formation.
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- - This study examines a zebrafish mutant that develops tumors in the optic pathway, specifically in the retina and optic nerve, linked to a specific genetic mutation associated with a high copy number transgene on chromosome 3.
- - Researchers discovered that a deletion of exons 2-5 of the lincRNAis18 gene does not trigger tumor development, as homozygous deletions of this gene do not lead to tumors, while the mutant strains show an 80-100% incidence of tumors by one year of age.
- - Transcriptome analysis revealed that tumor formation involves changes in gene expression related to glial cells, neural progenitors, and activation of key signaling pathways like Wnt, suggesting that certain glial cells may