Drug-induced liver injury in older people.

Drug-induced liver injury (DILI) is a rare, unpredictable, and potentially serious adverse reaction. It is induced by many drugs, herbs, and dietary supplements and represents a diagnostic challenge to clinicians. Older people (aged 65 years and older) are often polymedicated, and their declining physiological function affects drug pharmacokinetics.

Intermediate steroid withdrawal after renal transplantation and anti-HLA antibodies (HLA-Abs) development.

Introduction: Steroid withdrawal in renal transplantation is desirable to avoid their adverse effects. However, by decreasing the immunosuppression, could lead to an increased risk for the development of HLA-Abs.

Objective: Evaluate the relationship between steroid withdrawal and development of HLA-Abs in renal transplantation.