Publications by authors named "Judith Pfannkuche"
Article Synopsis
- The study examines how pro-inflammatory cytokines affect human annulus fibrosus cells (hAFCs) and their ability to sensitize dorsal root ganglion (DRG) cells.
- Celecoxib (cxb) was tested to see if it could inhibit this sensitization, with results showing that it effectively reduced PGE-2 production in hAFCs and lowered DRG cell sensitivity to bradykinin.
- Overall, the findings suggest that cxb may be beneficial in minimizing nerve sensitization related to inflamed hAFCs.
Low back pain (LBP) is a major reason for disability, and symptomatic intervertebral disc (IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases. Current treatment modalities for IDD include conservative and surgical strategies. Unfortunately, there is a significant number of patients in which conventional therapies fail with the result that these patients remain suffering from chronic pain and disability.
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