Drug development is a costly and timely process with high risks of failure during clinical trials. Although tissue models have significantly advanced over the years, thus fostering a transition from animal-derived models towards human-derived models, failure rates still remain high. Current cell-based assays are still not able to provide an accurate prediction of the clinical success or failure of a drug candidate.
View Article and Find Full Text PDFNon-pharmaceutical interventions (NPIs) to reduce the transmission of Covid-19 had different repercussions for domestic, regional and global value chains, but empirical data are sparse on specific dynamics, particularly on their implications for value-chain stakeholders' local livelihoods. Through research including weekly phone interviews (n = 273 from May to July 2020) with panellists in six Mozambican communities, our research traced firstly how the baobab and charcoal value chains were affected by Covid NPIs, particularly in terms of producers' livelihoods. Secondly, we ask how our findings advance our understanding of the role of civic-based stakeholder conventions and different types of power in building viable local livelihoods.
View Article and Find Full Text PDFThe United Nations' Sustainable Development Goals (UN SDGs) aspire to be integrated and indivisible, balance the three dimensions of sustainable development and transform our world by going beyond previously agreed language. Focusing on decoloniality and equity, we explore whether these aspirations are met in analysing five goals, their targets and indicators interlinking especially the economy-ecology spheres: SDGs 8 (economic growth), 9 (industry and innovation), 12 (sustainable production and consumption), 13 (climate action) and 15 (life on land). We examine two interconnected foci.
View Article and Find Full Text PDFNon-pharmaceutical interventions (NPIs) such as social distancing and travel restrictions have been introduced to prevent the spread of the novel coronavirus (hereinafter Covid). In many countries of the Global South, NPIs are affecting rural livelihoods, but in-depth empirical data on these impacts are limited. We traced the differentiated impacts of Covid NPIs throughout the start of the pandemic May to July 2020.
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