Prospective study of the association between abandoned dwellings and testosterone level on the development of behaviors leading to cannabis use disorder in boys.

Background: The role of testosterone in the development of behaviors presaging cannabis use and subsequently cannabis use disorder was investigated in a prospective study of 208 boys. It was theorized that adverse neighborhood correlates with testosterone level that in turn potentiates behaviors predisposing to cannabis consumption and subsequently diagnosis of cannabis use disorder.

Methods: Proportion of boarded-up dwellings in the 1990 census tract and testosterone level were recorded at baseline (ages 10-12), followed by assessments of assaultiveness and testosterone level (ages 12-14), social dominance/norm-violating behavior (SDNVB) (age 16), cannabis use (age 19), and cannabis use disorder (age 22).

Testosterone levels and sexual maturation predict substance use disorders in adolescent boys: a prospective study.

Background: This investigation determined whether testosterone level and sexual maturation in boys biased development of socially nonnormative behavior culminating in a substance use disorder (SUD).

Methods: The subjects were 179 boys recruited in late childhood through a high-risk paradigm. Path analysis was used to evaluate the influence of testosterone level and sexual maturation in early adolescence (age 12-14) on attitudes toward antisociality, affiliation with deviant peers, and social potency in middle adolescence (age 16), illicit drug use by late adolescence (age 19), and SUD in young adulthood (age 22).

Should we consider an acceptable drinking level specifically for postmenopausal women? Preliminary findings from the postmenopausal health disparities study.

Aims: There are substantial neuroendocrine differences between postmenopausal (PMP) women and women with cyclic ovarian function; thus there are differences in hormonal responses to 'acceptable' levels of drinking, i.e. 7 total weekly drinks (TWD).

Directions for unraveling the issue of alcohol and health disparities: findings from the Postmenopausal Health Disparities study.

The Postmenopausal Health Disparities Study (PHD Study) is a model for unraveling the underlying factors that may play a role in the health status and life expectancy disparities among racial and ethnic groups, with particular attention to effects of alcoholic beverage consumption. The study is bioepidemiologic; underlying mechanisms, rather than end points per se, are evaluated. The design is cross-sectional with historical prospective elements.

Thoughts on individualizing hormone replacement therapy based on the postmenopausal health disparities study data.

Background: This study presents an approach that can be used to address the controversy about the long-term risks and benefits of hormone replacement therapy (HRT).

Methods: Categories of estradiol (E(2)) levels based on the mean and standard deviation (SD) in postmenopausal women not treated with HRT were created. E(2) levels achieved in women treated with oral or patch replacement therapy were examined.

Predictors of postmenopausal body mass index and waist hip ratio in the oklahoma postmenopausal health disparities study.

Objective: The goal of the current study has been to examine systematically the respective roles of nutrition, exercise, menopausal weight gain, moderate drinking and smoking as determinants of body mass index (BMI) and waist hip ratio (WHR) in a setting in which the role of race or ethnic group could be simultaneously or individually evaluated as predictors of BMI and WHR. Because the use of estrogen replacement has been reported to affect estimates of body fat mass in postmenopausal women, endocrine factors have also been evaluated.

Methods: The design is cross-sectional with historical prospective elements.

Oral hormone replacement therapy: factors that influence the estradiol concentrations achieved in a multiracial study population.

The assumption that estradiol (E2) concentrations are reliably increased to therapeutic levels in postmenopausal women receiving hormone replacement therapy (HRT) has not been explicitly tested. Nor have factors that may modulate the E2 levels achieved been evaluated. The author examined E2 concentrations in a multiracial study population of 309 postmenopausal women treated with oral HRT and observed that 51.

Alcohol, Hormones, and Health in Postmenopausal Women.

Menopause is associated with increased risk for certain diseases. By affecting hormone levels, alcohol consumption might influence the occurrence or progress of these diseases.